On My Etsy Shop: Signed & Matted 5x7 La Santa Muerte Art Prints $20. Nuestra SeƱora de la Santa Muerte (Spanish for Our Lady of the Holy Death) or, colloquially, Santa Muerte (Holy Death), is a female deity (or folk saint depending on school of thought) in Mexican folk religion, particularly Folk Catholicism, venerated primarily in Mexico and the Southwestern United States. A personification of death, she is associated with healing, protection, and safe delivery to the afterlife by her devotees.